Release of Pharmaceutical Peptides in an Aggregated State: Using Fibrillar Polymorphism to Modulate Release Levels

Traditional approaches to achieve sustained delivery of pharmaceutical peptides traditionally use co-excipients (e.g., microspheres and hydrogels). Here, we investigate the release of an amyloidogenic glucagon analogue (3474) from an aggregated state and the influence of surfactants on this process....

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Bibliographic Details
Main Authors: Jens K. Madsen, Gunna Christiansen, Lise Giehm, Daniel E. Otzen
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:Colloids and Interfaces
Subjects:
Online Access:https://www.mdpi.com/2504-5377/3/1/42