Gene therapy mediated seizure suppression in Genetic Generalised Epilepsy: Neuropeptide Y overexpression in a rat model

Gene therapy mediated seizure suppression in Genetic Generalised Epilepsy: Neuropeptide Y overexpression in a rat model

Neuropeptide Y (NPY) is an important 36 amino acid peptide that is abundantly expressed in the mammalian CNS and is known to be an endogenous modulator of seizure activity, including in rat models of Genetic Generalised Epilepsy (GGE) with absence seizures. Studies have shown that viral-mediated “ge...

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Bibliographic Details
Main Authors: Kim L. Powell, Xavier Fitzgerald, Claire Shallue, Valentina Jovanovska, Matthias Klugmann, Georg Von Jonquieres, Terence J. O'Brien, Margaret J. Morris
Format: Article
Language:English
Published: Elsevier 2018-05-01
Series:Neurobiology of Disease
Subjects:
Neuropeptide Y
Genetic Generalised Epilepsy
Gene therapy
Adeno-associated viral vector
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996118300226

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http://www.sciencedirect.com/science/article/pii/S0969996118300226

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