Reduced miR-26b Expression in Megakaryocytes and Platelets Contributes to Elevated Level of Platelet Activation Status in Sepsis

Reduced miR-26b Expression in Megakaryocytes and Platelets Contributes to Elevated Level of Platelet Activation Status in Sepsis

In sepsis, platelets may become activated via toll-like receptors (TLRs), causing microvascular thrombosis. Megakaryocytes (MKs) also express these receptors; thus, severe infection may modulate thrombopoiesis. To explore the relevance of altered miRNAs in platelet activation upon sepsis, we first i...

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Bibliographic Details
Main Authors: Bernadett Szilágyi, Zsolt Fejes, Szilárd Póliska, Marianna Pócsi, Zsolt Czimmerer, Andreas Patsalos, Ferenc Fenyvesi, Ágnes Rusznyák, György Nagy, György Kerekes, Mariann Berhés, Ildikó Szűcs, Satya P. Kunapuli, János Kappelmayer, Béla Nagy
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:International Journal of Molecular Sciences
Subjects:
platelet activation
microrna
selp
megakaryocyte
sepsis
inflammation
meg-01
Online Access:https://www.mdpi.com/1422-0067/21/3/866

Internet

https://www.mdpi.com/1422-0067/21/3/866

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