In vivo TCR signaling in CD4+ T cells imprints a cell-intrinsic, transient low motility pattern independent of chemokine receptor expression levels or microtubular network, integrin and protein kinase C activity

In vivo TCR signaling in CD4+ T cells imprints a cell-intrinsic, transient low motility pattern independent of chemokine receptor expression levels or microtubular network, integrin and protein kinase C activity

Intravital imaging has revealed that T cells change their migratory behavior during physiological activation inside lymphoid tissue. Yet, it remains less well investigated how the intrinsic migratory capacity of activated T cells is regulated by chemokine receptor levels or other regulatory elements...

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Bibliographic Details
Main Authors: Markus eAckerknecht, Mark A Hauser, Daniel F Legler, Jens Volker Stein
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-06-01
Series:Frontiers in Immunology
Subjects:
Stathmin
Lymph Node
PKC
T cell activation
CCR7
CD4+ T cell migration
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00297/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00297/full

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