TGF-β-Neutralizing Antibody 1D11 Enhances Cytarabine-Induced Apoptosis in AML Cells in the Bone Marrow Microenvironment.

TGF-β-Neutralizing Antibody 1D11 Enhances Cytarabine-Induced Apoptosis in AML Cells in the Bone Marrow Microenvironment.

Hypoxia and interactions with bone marrow (BM) stromal cells have emerged as essential components of the leukemic BM microenvironment in promoting leukemia cell survival and chemoresistance. High levels of transforming growth factor beta 1 (TGFβ1) produced by BM stromal cells in the BM niche regulat...

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Bibliographic Details
Main Authors: Yoko Tabe, Yue Xi Shi, Zhihong Zeng, Linhua Jin, Masato Shikami, Yasuhito Hatanaka, Takashi Miida, Frank J Hsu, Michael Andreeff, Marina Konopleva
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3695026?pdf=render

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http://europepmc.org/articles/PMC3695026?pdf=render

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