Antisense inhibition of apoB synthesis with mipomersen reduces plasma apoC-III and apoC-III-containing lipoproteins

Antisense inhibition of apoB synthesis with mipomersen reduces plasma apoC-III and apoC-III-containing lipoproteins

Mipomersen, an antisense oligonucleotide that reduces hepatic production of apoB, has been shown in phase 2 studies to decrease plasma apoB, LDL cholesterol (LDL-C), and triglycerides. ApoC-III inhibits VLDL and LDL clearance, and it stimulates inflammatory responses in vascular cells. Concentration...

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Bibliographic Details
Main Authors: Jeremy D. Furtado, Mark K. Wedel, Frank M. Sacks
Format: Article
Language:English
Published: Elsevier 2012-04-01
Series:Journal of Lipid Research
Subjects:
apolipoprotein C-III
apolipoprotein B
apolipoprotein E
cholesterol
atherosclerosis
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520405723

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http://www.sciencedirect.com/science/article/pii/S0022227520405723

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