Targeting Beclin1 as an Adjunctive Therapy against HIV Using Mannosylated Polyethylenimine Nanoparticles

Targeting Beclin1 as an Adjunctive Therapy against HIV Using Mannosylated Polyethylenimine Nanoparticles

Using nanoparticle-based RNA interference (RNAi), we have previously shown that silencing the host autophagic protein, Beclin1, in HIV-infected human microglia and astrocytes restricts HIV replication and its viral-associated inflammatory responses. Here, we confirmed the efficacy of Beclin1 small i...

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Bibliographic Details
Main Authors: Myosotys Rodriguez, Yemmy Soler, Mohan Kumar Muthu Karuppan, Yuling Zhao, Elena V. Batrakova, Nazira El-Hage
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Pharmaceutics
Subjects:
Beclin1
intranasal delivery
in vivo imaging system
polyethylenimine nanoparticle
HIV
Online Access:https://www.mdpi.com/1999-4923/13/2/223

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https://www.mdpi.com/1999-4923/13/2/223

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