Fluoxetine attenuates neuroinflammation in early brain injury after subarachnoid hemorrhage: a possible role for the regulation of TLR4/MyD88/NF-κB signaling pathway

Fluoxetine attenuates neuroinflammation in early brain injury after subarachnoid hemorrhage: a possible role for the regulation of TLR4/MyD88/NF-κB signaling pathway

Abstract Background Neuroinflammation is closely associated with functional outcome in subarachnoid hemorrhage (SAH) patients. Our recent study demonstrated that fluoxetine inhibited NLRP3 inflammasome activation and attenuated necrotic cell death in early brain injury after SAH, while the effects a...

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Bibliographic Details
Main Authors: Fu-yi Liu, Jing Cai, Chun Wang, Wu Ruan, Guo-ping Guan, Hai-zhou Pan, Jian-ru Li, Cong Qian, Jing-sen Chen, Lin Wang, Gao Chen
Format: Article
Language:English
Published: BMC 2018-12-01
Series:Journal of Neuroinflammation
Subjects:
Subarachnoid hemorrhage
Early brain injury
Neuroinflammation
Fluoxetine
Online Access:http://link.springer.com/article/10.1186/s12974-018-1388-x

Internet

http://link.springer.com/article/10.1186/s12974-018-1388-x

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