Reduced Anti-Histone Antibodies and Increased Risk of Rheumatoid Arthritis Associated with a Single Nucleotide Polymorphism in PADI4 in North Americans

Reduced Anti-Histone Antibodies and Increased Risk of Rheumatoid Arthritis Associated with a Single Nucleotide Polymorphism in PADI4 in North Americans

Autoantibodies against citrullinated proteins are a hallmark of rheumatoid arthritis, a destructive inflammatory arthritis. Peptidylarginine deiminase 4 (PAD4) has been hypothesized to contribute to rheumatoid arthritis by citrullinating histones to induce neutrophil extracellular traps (NETs), whic...

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Bibliographic Details
Main Authors: Aisha M. Mergaert, Mandar Bawadekar, Thai Q. Nguyen, Laura Massarenti, Caitlyn L. Holmes, Ryan Rebernick, Steven J. Schrodi, Miriam A. Shelef
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:International Journal of Molecular Sciences
Subjects:
rheumatoid arthritis
neutrophil extracellular trap
autoantibody
peptidylarginine deiminase 4
single nucleotide polymorphism
Online Access:https://www.mdpi.com/1422-0067/20/12/3093

Internet

https://www.mdpi.com/1422-0067/20/12/3093

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