Age-related sexual dimorphism in temporal discrimination and in adult-onset dystonia suggests GABAergic mechanisms.

Age-related sexual dimorphism in temporal discrimination and in adult-onset dystonia suggests GABAergic mechanisms.

Background: Adult onset isolated focal dystonia presenting in early adult life is more frequent in men whereas in middle age it is female predominant. Temporal discrimination, an endophenotype of adult onset idiopathic isolated focal dystonia, shows evidence of sexual dimorphism in healthy participa...

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Bibliographic Details
Main Authors: John S. Butler, Ines M Beiser, Laura eWilliams, Eavan eMcGovern, Fiona eMolloy, Tim eLynch, Daniel G Healy, Helena eMoore, Richard eWalsh, Richard B Reilly, Sean eO'Riordan, Cathal eWalsh, Michael eHutchinson
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-12-01
Series:Frontiers in Neurology
Subjects:
sexual dimorphism
Penetrance
temporal discrimination
Sex Distribution
Cervical dystonia
Disease expression
Online Access:http://journal.frontiersin.org/Journal/10.3389/fneur.2015.00258/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fneur.2015.00258/full

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