CCI-779 Inhibits Rhabdomyosarcoma Xenograft Growth by an Antiangiogenic Mechanism Linked to the Targeting of mTOR/Hif-1α/VEGF Signaling

CCI-779 Inhibits Rhabdomyosarcoma Xenograft Growth by an Antiangiogenic Mechanism Linked to the Targeting of mTOR/Hif-1α/VEGF Signaling

Angiogenesis is one of the critical steps in tumor growth and metastasis. The goal of this study was to evaluate whether the antitumor activity of CCI-779 is related to antiangiogenic effects in vivo in tumors of mice bearing human rhabdomyosarcoma (RMS) xenografts. We now demonstrate that CCI-779...

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Bibliographic Details
Main Authors: Xiaolin Wan, Na Shen, Arnulfo Mendoza, Chand Khanna, Lee J. Helman
Format: Article
Language:English
Published: Elsevier 2006-05-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
CCI-779
mTOR
Hif-1α
VEGF
rhabdomyosarcoma xenografts
Online Access:http://www.sciencedirect.com/science/article/pii/S147655860680059X

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http://www.sciencedirect.com/science/article/pii/S147655860680059X

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