Salmon and human thrombin differentially regulate radicular pain, glial-induced inflammation and spinal neuronal excitability through protease-activated receptor-1.

Salmon and human thrombin differentially regulate radicular pain, glial-induced inflammation and spinal neuronal excitability through protease-activated receptor-1.

Chronic neck pain is a major problem with common causes including disc herniation and spondylosis that compress the spinal nerve roots. Cervical nerve root compression in the rat produces sustained behavioral hypersensitivity, due in part to the early upregulation of pro-inflammatory cytokines, the...

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Bibliographic Details
Main Authors: Jenell R Smith, Peter P Syre, Shaina A Oake, Kristen J Nicholson, Christine L Weisshaar, Katrina Cruz, Robert Bucki, Bethany C Baumann, Paul A Janmey, Beth A Winkelstein
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24278231/?tool=EBI

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https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24278231/?tool=EBI

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