Epithelium intrinsic vitamin A signaling co-ordinates pathogen clearance in the gut via IL-18.

Epithelium intrinsic vitamin A signaling co-ordinates pathogen clearance in the gut via IL-18.

Intestinal epithelial cells (IECs) are at the forefront of host-pathogen interactions, coordinating a cascade of immune responses to protect against pathogens. Here we show that IEC-intrinsic vitamin A signaling restricts pathogen invasion early in the infection and subsequently activates immune cel...

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Bibliographic Details
Main Authors: Namrata Iyer, Mayara Grizotte-Lake, Kellyanne Duncan, Sarah R Gordon, Ana C S Palmer, Crystle Calvin, Guo Zhong, Nina Isoherranen, Shipra Vaishnava
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-04-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1008360

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https://doi.org/10.1371/journal.ppat.1008360

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