Hypoxic BMSC-derived exosomal miRNAs promote metastasis of lung cancer cells via STAT3-induced EMT

Hypoxic BMSC-derived exosomal miRNAs promote metastasis of lung cancer cells via STAT3-induced EMT

Abstract Background Metastasis is the main cause of lung cancer mortality. Bone marrow-derived mesenchymal stem cells (BMSCs) are a component of the cancer microenvironment and contribute to cancer progression. Intratumoral hypoxia affects both cancer and stromal cells. Exosomes are recognized as me...

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Bibliographic Details
Main Authors: Xina Zhang, Buqing Sai, Fan Wang, Lujuan Wang, Yuhui Wang, Leliang Zheng, Guiyuan Li, Jingqun Tang, Juanjuan Xiang
Format: Article
Language:English
Published: BMC 2019-03-01
Series:Molecular Cancer
Subjects:
BMSCs, exosomal miRNA
Metastasis
EMT
STAT3
Online Access:http://link.springer.com/article/10.1186/s12943-019-0959-5

Internet

http://link.springer.com/article/10.1186/s12943-019-0959-5

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