Activation of Glutathione Peroxidase 4 as a Novel Anti-inflammatory Strategy

Activation of Glutathione Peroxidase 4 as a Novel Anti-inflammatory Strategy

The anti-oxidative enzyme, glutathione peroxidase 4 (GPX4), helps to promote inflammation resolution by eliminating oxidative species produced by the arachidonic acid (AA) metabolic network. Up-regulating its activity has been proposed as a promising strategy for inflammation intervention. In the pr...

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Bibliographic Details
Main Authors: Cong Li, Xiaobing Deng, Xiaowen Xie, Ying Liu, José Pedro Friedmann Angeli, Luhua Lai
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Pharmacology
Subjects:
arachidonic acid metabolic network
GPX4
enzyme activator
allosterism
drug discovery
anti-inflammatory
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.01120/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2018.01120/full

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