Efficacious recombinant influenza vaccines produced by high yield bacterial expression: a solution to global pandemic and seasonal needs.

Efficacious recombinant influenza vaccines produced by high yield bacterial expression: a solution to global pandemic and seasonal needs.

It is known that physical linkage of TLR ligands and vaccine antigens significantly enhances the immunopotency of the linked antigens. We have used this approach to generate novel influenza vaccines that fuse the globular head domain of the protective hemagglutinin (HA) antigen with the potent TLR5...

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Bibliographic Details
Main Authors: Langzhou Song, Valerian Nakaar, Uma Kavita, Albert Price, Jim Huleatt, Jie Tang, Andrea Jacobs, Ge Liu, Yan Huang, Priyanka Desai, Gail Maksymiuk, Virginia Takahashi, Scott Umlauf, Lucia Reiserova, Rodney Bell, Hong Li, Yi Zhang, William F McDonald, T J Powell, Lynda Tussey
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2373928?pdf=render

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http://europepmc.org/articles/PMC2373928?pdf=render

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