BDNF-TrkB pathway mediates neuroprotection of hydrogen sulfide against formaldehyde-induced toxicity to PC12 cells.

Formaldehyde (FA) is a common environmental contaminant that has toxic effects on the central nervous system (CNS). Our previous data demonstrated that hydrogen sulfide (H2S), the third endogenous gaseous mediator, has protective effects against FA-induced neurotoxicity. As is known to all, Brain-de...

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Bibliographic Details
Main Authors: Jia-Mei Jiang, Cheng-Fang Zhou, Sheng-Lan Gao, Ying Tian, Chun-Yan Wang, Li Wang, Hong-Feng Gu, Xiao-Qing Tang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4352058?pdf=render