Stage 1 Registered Report: Variation in neurodevelopmental outcomes in children with sex chromosome trisomies: protocol for a test of the double hit hypothesis [version 2; referees: 1 approved, 2 approved with reservations]

Background: The presence of an extra sex chromosome is associated with an increased rate of neurodevelopmental difficulties involving language. Group averages, however, obscure a wide range of outcomes. Hypothesis: The 'double hit' hypothesis proposes that the adverse impact of the extra s...

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Bibliographic Details
Main Authors: Dianne F. Newbury, Nuala H. Simpson, Paul A. Thompson, Dorothy V. M. Bishop
Format: Article
Language:English
Published: Wellcome 2018-04-01
Series:Wellcome Open Research
Online Access:https://wellcomeopenresearch.org/articles/3-10/v2