Mechanical strain downregulates C/EBPβ in MSC and decreases endoplasmic reticulum stress.

Mechanical strain downregulates C/EBPβ in MSC and decreases endoplasmic reticulum stress.

Exercise prevents marrow mesenchymal stem cell (MSC) adipogenesis, reversing trends that accompany aging and osteoporosis. Mechanical input, the in-vitro analogue to exercise, limits PPARγ expression and adipogenesis in MSC. We considered whether C/EBPβ might be mechanoresponsive as it is upstream t...

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Bibliographic Details
Main Authors: Maya Styner, Mark B Meyer, Kornelia Galior, Natasha Case, Zhihui Xie, Buer Sen, William R Thompson, John Wesley Pike, Janet Rubin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3520924?pdf=render

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http://europepmc.org/articles/PMC3520924?pdf=render

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