Acamprosate in a mouse model of fragile X syndrome: modulation of spontaneous cortical activity, ERK1/2 activation, locomotor behavior, and anxiety

Acamprosate in a mouse model of fragile X syndrome: modulation of spontaneous cortical activity, ERK1/2 activation, locomotor behavior, and anxiety

Abstract Background Fragile X Syndrome (FXS) occurs as a result of a silenced fragile X mental retardation 1 gene (FMR1) and subsequent loss of fragile X mental retardation protein (FMRP) expression. Loss of FMRP alters excitatory/inhibitory signaling balance, leading to increased neuronal hyperexci...

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Bibliographic Details
Main Authors: Tori L. Schaefer, Matthew H. Davenport, Lindsay M. Grainger, Chandler K. Robinson, Anthony T. Earnheart, Melinda S. Stegman, Anna L. Lang, Amy A. Ashworth, Gemma Molinaro, Kimberly M. Huber, Craig A. Erickson
Format: Article
Language:English
Published: BMC 2017-06-01
Series:Journal of Neurodevelopmental Disorders
Subjects:
Electrophysiology
Hyperactivity
Fragile X syndrome
Anxiety
Extracellular signal-related kinase
Dendritic spine density
Online Access:http://link.springer.com/article/10.1186/s11689-017-9184-y

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http://link.springer.com/article/10.1186/s11689-017-9184-y

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