Detecting the limits of regulatory element conservation and divergence estimation using pairwise and multiple alignments

<p>Abstract</p> <p>Background</p> <p>Molecular evolutionary studies of noncoding sequences rely on multiple alignments. Yet how multiple alignment accuracy varies across sequence types, tree topologies, divergences and tools, and further how this variation impacts speci...

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Bibliographic Details
Main Authors: Iyer Venky N, Moses Alan M, Pollard Daniel A, Eisen Michael B
Format: Article
Language:English
Published: BMC 2006-08-01
Series:BMC Bioinformatics
Online Access:http://www.biomedcentral.com/1471-2105/7/376