A New Pharmacogenetic Algorithm to Predict the Most Appropriate Dosage of Acenocoumarol for Stable Anticoagulation in a Mixed Spanish Population.

There is a strong association between genetic polymorphisms and the acenocoumarol dosage requirements. Genotyping the polymorphisms involved in the pharmacokinetics and pharmacodynamics of acenocoumarol before starting anticoagulant therapy would result in a better quality of life and a more efficie...

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Main Authors: Hoi Y Tong, Cristina Lucía Dávila-Fajardo, Alberto M Borobia, Luis Javier Martínez-González, Rubin Lubomirov, Laura María Perea León, María J Blanco Bañares, Xando Díaz-Villamarín, Carmen Fernández-Capitán, José Cabeza Barrera, Antonio J Carcas, PGX-ACE Investigators Group
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4792430?pdf=render