G6PD Polymorphisms and Hemolysis After Antimalarial Treatment With Low Single-Dose Primaquine: A Pooled Analysis of Six African Clinical Trials

G6PD Polymorphisms and Hemolysis After Antimalarial Treatment With Low Single-Dose Primaquine: A Pooled Analysis of Six African Clinical Trials

Primaquine (PQ) is an antimalarial drug with the potential to reduce malaria transmission due to its capacity to clear mature Plasmodium falciparum gametocytes in the human host. However, the large-scale roll-out of PQ has to be counterbalanced by the additional risk of drug-induced hemolysis in ind...

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Bibliographic Details
Main Authors: Nuno Sepúlveda, Lynn Grignard, Jonathan Curry, Laleta Mahey, Guido J. H. Bastiaens, Alfred B. Tiono, Joseph Okebe, Sam A. Coulibaly, Bronner P. Gonçalves, Muna Affara, Alphonse Ouédraogo, Edith C. Bougouma, Guillaume S. Sanou, Issa Nébié, Kjerstin Lanke, Sodiomon B. Sirima, Alassane Dicko, Umberto d’Alessandro, Taane G. Clark, Susana Campino, Ingrid Chen, Alice C. Eziefula, Roly Gosling, Teun Bousema, Chris Drakeley
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Genetics
Subjects:
genetic association study
clinical trials
malaria
drug safety
hemoglobin
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2021.645688/full

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https://www.frontiersin.org/articles/10.3389/fgene.2021.645688/full

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