CRISPR Start-Loss: A Novel and Practical Alternative for Gene Silencing through Base-Editing-Induced Start Codon Mutations

CRISPR Start-Loss: A Novel and Practical Alternative for Gene Silencing through Base-Editing-Induced Start Codon Mutations

CRISPR-Cas9-mediated gene knockout and base-editing-associated induction of STOP codons (iSTOP) have been widely used to exterminate the function of a coding gene, while they have been reported to exhibit side effects. In this study, we propose a novel and practical alternative method referred to as...

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Bibliographic Details
Main Authors: Siyu Chen, Wanhua Xie, Zhiquan Liu, Huanhuan Shan, Mao Chen, Yuning Song, Hao Yu, Liangxue Lai, Zhanjun Li
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
CRISPR start-loss
start codon
loss-of-function
Fgf5
Otc
rabbits
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253120302262

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http://www.sciencedirect.com/science/article/pii/S2162253120302262

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