An Anti-MICA/B Antibody and IL-15 Rescue Altered NKG2D-Dependent NK Cell Responses in Hepatocellular Carcinoma

An Anti-MICA/B Antibody and IL-15 Rescue Altered NKG2D-Dependent NK Cell Responses in Hepatocellular Carcinoma

Natural killer (NK) cells play a pivotal role in cancer immune surveillance, and activating the receptor/ligand interaction may contribute to control the development and evolution of hepatocellular carcinoma (HCC). We investigated the role of the natural killer group 2 member D (NKG2D) activating re...

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Bibliographic Details
Main Authors: Stefania Mantovani, Stefania Varchetta, Dalila Mele, Matteo Donadon, Guido Torzilli, Cristiana Soldani, Barbara Franceschini, Camillo Porta, Silvia Chiellino, Paolo Pedrazzoli, Roberto Santambrogio, Matteo Barabino, Claudia Cigala, Gaetano Piccolo, Enrico Opocher, Marcello Maestri, Angelo Sangiovanni, Stefano Bernuzzi, Florence Lhospice, Manel Kraiem, Mario Umberto Mondelli, Barbara Oliviero
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Cancers
Subjects:
natural killer cells
HCC
sorafenib
immunotherapy
innate immunity
Online Access:https://www.mdpi.com/2072-6694/12/12/3583

Internet

https://www.mdpi.com/2072-6694/12/12/3583

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