A Micropatterned Human‐Specific Neuroepithelial Tissue for Modeling Gene and Drug‐Induced Neurodevelopmental Defects

A Micropatterned Human‐Specific Neuroepithelial Tissue for Modeling Gene and Drug‐Induced Neurodevelopmental Defects

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Abstract The generation of structurally standardized human pluripotent stem cell (hPSC)‐derived neural embryonic tissues has the potential to model genetic and environmental mediators of early neurodevelopmental defects. Current neural patterning systems have so far focused on directing cell fate sp...

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Bibliographic Details
Main Authors: Geetika Sahni, Shu‐Yung Chang, Jeremy Teo Choon Meng, Jerome Zu Yao Tan, Jean Jacques Clement Fatien, Carine Bonnard, Kagistia Hana Utami, Puck Wee Chan, Thong Teck Tan, Umut Altunoglu, Hülya Kayserili, Mahmoud Pouladi, Bruno Reversade, Yi‐Chin Toh
Format: Article
Language:English
Published: Wiley 2021-03-01
Series:Advanced Science
Subjects:
human pluripotent stem cells
micropatterning
morphogenesis
neurodevelopmental defects
neuroepithelium
Online Access:https://doi.org/10.1002/advs.202001100

Internet

https://doi.org/10.1002/advs.202001100

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