Mathematical Modeling and Parameter Estimation of Intracellular Signaling Pathway: Application to LPS-induced NFκB Activation and TNFα Production in Macrophages

Mathematical Modeling and Parameter Estimation of Intracellular Signaling Pathway: Application to LPS-induced NFκB Activation and TNFα Production in Macrophages

Due to the intrinsic stochasticity, the signaling dynamics in a clonal population of cells exhibit cell-to-cell variability at the single-cell level, which is distinct from the population-average dynamics. Frequently, flow cytometry is widely used to acquire the single-cell level measurements by blo...

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Bibliographic Details
Main Authors: Dongheon Lee, Yufang Ding, Arul Jayaraman, Joseph S. Kwon
Format: Article
Language:English
Published: MDPI AG 2018-02-01
Series:Processes
Subjects:
systems biology
parameter estimation
NFκB signaling pathway
lipopolysaccharide
flow cytometry
sensitivity analysis
Online Access:http://www.mdpi.com/2227-9717/6/3/21

Internet

http://www.mdpi.com/2227-9717/6/3/21

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