Potential treatment for chronic myeloid leukemia using microRNA: in silico comparison between plants and human microRNAs in targeting BCR-ABL1 gene

Potential treatment for chronic myeloid leukemia using microRNA: in silico comparison between plants and human microRNAs in targeting BCR-ABL1 gene

Abstract Background Chronic myeloid leukemia (CML) is a myeloproliferative disorder characterized by the expression of the BCR-ABL1 fusion gene. Tyrosine kinase inhibitors (TKI) are used to treat CML, but mutations in the tyrosine kinase domain contribute to CML chemo-resistance. Therefore, finding...

Full description

Bibliographic Details
Main Authors: Syarifah Faezah Syed Mohamad, Marjanu Hikmah Elias
Format: Article
Language:English
Published: SpringerOpen 2021-05-01
Series:Egyptian Journal of Medical Human Genetics
Subjects:
BCR-ABL1
Chronic myeloid leukemia
Cross-kingdom
In silico
MicroRNA
3′ untranslated region
Online Access:https://doi.org/10.1186/s43042-021-00156-x

Internet

https://doi.org/10.1186/s43042-021-00156-x

Similar Items