Standardized Salvia miltiorrhiza Extract Suppresses Hepatic Stellate Cell Activation and Attenuates Steatohepatitis Induced by a Methionine-Choline Deficient Diet in Mice

Standardized Salvia miltiorrhiza Extract Suppresses Hepatic Stellate Cell Activation and Attenuates Steatohepatitis Induced by a Methionine-Choline Deficient Diet in Mice

The aim of this study was to examine the effect of standardized extract of Salvia miltiorrhiza (SME) on gene and protein expression of non-alcoholic steatohepatitis (NASH)-related factors in activated human hepatic stellate cells (HSC), and in mice with steatohepatitis induced by a methionine-cholin...

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Bibliographic Details
Main Authors: Hak Sung Lee, Woo-Chan Son, Jae-Eun Ryu, Bon Am Koo, Yeong Shik Kim
Format: Article
Language:English
Published: MDPI AG 2014-06-01
Series:Molecules
Subjects:
Salvia miltiorrhiza
non-alcoholic steatohepatitis (NASH)
methionine-choline deficient (MCD)
hepatic stellate cell (HSC)
TGF-β1
TNF-α
MMP-2
MMP-9
tanshinone IIA
Online Access:http://www.mdpi.com/1420-3049/19/6/8189

Internet

http://www.mdpi.com/1420-3049/19/6/8189

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