Inhibition of IL-34 Unveils Tissue-Selectivity and Is Sufficient to Reduce Microglial Proliferation in a Model of Chronic Neurodegeneration

Inhibition of IL-34 Unveils Tissue-Selectivity and Is Sufficient to Reduce Microglial Proliferation in a Model of Chronic Neurodegeneration

The proliferation and activation of microglia, the resident macrophages in the brain, is a hallmark of many neurodegenerative diseases such as Alzheimer's disease (AD) and prion disease. Colony stimulating factor 1 receptor (CSF1R) is critically involved in regulating microglial proliferation,...

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Bibliographic Details
Main Authors: Juliane Obst, Emilie Simon, Maria Martin-Estebane, Elena Pipi, Liana M. Barkwill, Ivette Gonzalez-Rivera, Fergus Buchanan, Alan R. Prescott, Dorte Faust, Simon Fox, Janet Brownlees, Debra Taylor, V. Hugh Perry, Hugh Nuthall, Peter J. Atkinson, Eric Karran, Carol Routledge, Diego Gomez-Nicola
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Immunology
Subjects:
CSF1R (colony-stimulating factor 1 receptor)
prion disease
tissue-resident macrophage
chronic neurodegeneration
proliferation
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.579000/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.579000/full

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