Temperature-dependent regulation of upstream open reading frame translation in S. cerevisiae

Abstract Background Translation of an mRNA in eukaryotes starts at an AUG codon in most cases, but near-cognate codons (NCCs) such as UUG, ACG, and AUU can also be used as start sites at low levels in Saccharomyces cerevisiae. Initiation from NCCs or AUGs in the 5′-untranslated regions (UTRs) of mRN...

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Bibliographic Details
Main Authors: Shardul D. Kulkarni, Fujun Zhou, Neelam Dabas Sen, Hongen Zhang, Alan G. Hinnebusch, Jon R. Lorsch
Format: Article
Language:English
Published: BMC 2019-12-01
Series:BMC Biology
Online Access:https://doi.org/10.1186/s12915-019-0718-5