Inhibition of protein FAK enhances 5-FU chemosensitivity to gastric carcinoma via p53 signaling pathways

Inhibition of protein FAK enhances 5-FU chemosensitivity to gastric carcinoma via p53 signaling pathways

The small molecule drug 5-fluorouracil (5-FU) is widely used in the treatment for gastric cancer (GC), however, it exerts poor efficacy and is associated with acquired and intrinsic resistance. Focal adhesion kinase (FAK), a non-receptor tyrosine kinase, plays a key role in adhesion, migration, and...

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Bibliographic Details
Main Authors: Jingjing Hou, Yuyu Tan, Chen Su, Tao Wang, Zhixing Gao, Dan Song, Jiabao Zhao, Yueting Liao, Xiaotian Liu, Ying Jiang, Qian Feng, Zhong Wan, Yongsheng Yu
Format: Article
Language:English
Published: Elsevier 2020-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
Gastric carcinoma
FAK
RNA interference
5-FU
Chemosensitivity
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037019302144

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http://www.sciencedirect.com/science/article/pii/S2001037019302144

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