DNA Methylation of TLR4, VEGFA, and DEFA5 Is Associated With Necrotizing Enterocolitis in Preterm Infants

DNA Methylation of TLR4, VEGFA, and DEFA5 Is Associated With Necrotizing Enterocolitis in Preterm Infants

Background: Epigenetic changes, such as DNA methylation, may contribute to an increased susceptibility for developing necrotizing enterocolitis (NEC) in preterm infants. We assessed DNA methylation in five NEC-associated genes, selected from literature: EPO, VEGFA, ENOS, DEFA5, and TLR4 in infants w...

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Bibliographic Details
Main Authors: Daphne H. Klerk, Torsten Plösch, Rikst Nynke Verkaik-Schakel, Jan B. F. Hulscher, Elisabeth M. W. Kooi, Arend F. Bos
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Pediatrics
Subjects:
neonatology
DNA methylation
epigenetics
preterm infant
necrotizing enterocolitis
Toll-like receptor 4
Online Access:https://www.frontiersin.org/articles/10.3389/fped.2021.630817/full

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https://www.frontiersin.org/articles/10.3389/fped.2021.630817/full

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