An Alternative Binding Mode of IGHV3-53 Antibodies to the SARS-CoV-2 Receptor Binding Domain

An Alternative Binding Mode of IGHV3-53 Antibodies to the SARS-CoV-2 Receptor Binding Domain

Summary: IGHV3-53-encoded neutralizing antibodies are commonly elicited during SARS-CoV-2 infection and target the receptor-binding domain (RBD) of the spike (S) protein. Such IGHV3-53 antibodies generally have a short CDR H3 because of structural constraints in binding the RBD (mode A). However, a...

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Bibliographic Details
Main Authors: Nicholas C. Wu, Meng Yuan, Hejun Liu, Chang-Chun D. Lee, Xueyong Zhu, Sandhya Bangaru, Jonathan L. Torres, Tom G. Caniels, Philip J.M. Brouwer, Marit J. van Gils, Rogier W. Sanders, Andrew B. Ward, Ian A. Wilson
Format: Article
Language:English
Published: Elsevier 2020-10-01
Series:Cell Reports
Subjects:
COVID-19
SARS-CoV-2
antibodies
x-ray crystallography
spike protein
receptor-binding domain
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720312638

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http://www.sciencedirect.com/science/article/pii/S2211124720312638

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