[18F]FEPPA a TSPO Radioligand: Optimized Radiosynthesis and Evaluation as a PET Radiotracer for Brain Inflammation in a Peripheral LPS-Injected Mouse Model

[18F]FEPPA a TSPO Radioligand: Optimized Radiosynthesis and Evaluation as a PET Radiotracer for Brain Inflammation in a Peripheral LPS-Injected Mouse Model

[18F]FEPPA is a specific ligand for the translocator protein of 18 kDa (TSPO) used as a positron emission tomography (PET) biomarker for glial activation and neuroinflammation. [18F]FEPPA radiosynthesis was optimized to assess in a mouse model the cerebral inflammation induced by an intraperitoneal...

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Bibliographic Details
Main Authors: Nicolas Vignal, Salvatore Cisternino, Nathalie Rizzo-Padoin, Carine San, Fortune Hontonnou, Thibaut Gelé, Xavier Declèves, Laure Sarda-Mantel, Benoît Hosten
Format: Article
Language:English
Published: MDPI AG 2018-06-01
Series:Molecules
Subjects:
[18F]FEPPA
TSPO
brain inflammation
small-animal PET imaging
radiolabeling
radiotracer metabolism
Online Access:http://www.mdpi.com/1420-3049/23/6/1375

Internet

http://www.mdpi.com/1420-3049/23/6/1375

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