27-Hydroxycholesterol Contributes to Lysosomal Membrane Permeabilization-Mediated Pyroptosis in Co-cultured SH-SY5Y Cells and C6 Cells

27-Hydroxycholesterol Contributes to Lysosomal Membrane Permeabilization-Mediated Pyroptosis in Co-cultured SH-SY5Y Cells and C6 Cells

Purpose: Emerging evidence suggests that 27-Hydroxycholesterol (27-OHC) causes neurodegenerative diseases through the induction of cytotoxicity and cholesterol metabolism disorder. The objective of this study is to determine the impacts of 27-OHC on lysosomal membrane permeabilization (LMP) and pyro...

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Bibliographic Details
Main Authors: Si Chen, Cui Zhou, Huiyan Yu, Lingwei Tao, Yu An, Xiaona Zhang, Ying Wang, Yushan Wang, Rong Xiao
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Molecular Neuroscience
Subjects:
27-hydroxycholesterol
lysosomal membrane permeabilization
pyroptosis
cell co-culture
SH-SY5Y cells and C6 cells
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2019.00014/full

Internet

https://www.frontiersin.org/article/10.3389/fnmol.2019.00014/full

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