Signalling mechanisms regulating phenotypic changes in breast cancer cells

Signalling mechanisms regulating phenotypic changes in breast cancer cells

In MCF-7 breast cancer cells epidermal growth factor (EGF) induces cell proliferation, whereas heregulin (HRG)/neuregulin (NRG) induces irreversible phenotypic changes accompanied by lipid accumulation. Although these changes in breast cancer cells resemble processes that take place in the tissue, t...

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Bibliographic Details
Main Authors: Natalia Volinsky, Cormac J. McCarthy, Alex von Kriegsheim, Nina Saban, Mariko Okada‑Hatakeyama, Walter Kolch, Boris N. Kholodenko
Format: Article
Language:English
Published: Portland Press, Biochemical Society 2015-03-01
Series:Bioscience Reports
Subjects:
breast cancer
cell fate decisions
lipid accumulation
MCF-7
mTOR
PI3 kinase
receptor tyrosine kinases signalling pathways
Online Access:http://www.bioscirep.org/bsr/035/e178/bsr035e178.htm

Internet

http://www.bioscirep.org/bsr/035/e178/bsr035e178.htm

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