Deletion of CGI-58 or adipose triglyceride lipase differently affects macrophage function and atherosclerosis[S]

Deletion of CGI-58 or adipose triglyceride lipase differently affects macrophage function and atherosclerosis[S]

Cellular TG stores are efficiently hydrolyzed by adipose TG lipase (ATGL). Its coactivator comparative gene identification-58 (CGI-58) strongly increases ATGL-mediated TG catabolism in cell culture experiments. To investigate the consequences of CGI-58 deficiency in murine macrophages, we generated...

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Bibliographic Details
Main Authors: Madeleine Goeritzer, Stefanie Schlager, Branislav Radovic, Corina T. Madreiter, Silvia Rainer, Gwynneth Thomas, Caleb C. Lord, Jessica Sacks, Amanda L. Brown, Nemanja Vujic, Sascha Obrowsky, Vinay Sachdev, Dagmar Kolb, Prakash G. Chandak, Wolfgang F. Graier, Wolfgang Sattler, J. Mark Brown, Dagmar Kratky
Format: Article
Language:English
Published: Elsevier 2014-12-01
Series:Journal of Lipid Research
Subjects:
inflammation
lipid droplets
storage diseases
comparative gene identification-58
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520366967

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http://www.sciencedirect.com/science/article/pii/S0022227520366967

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