Combined epigenetic/genetic study identified an ALS age of onset modifier

Combined epigenetic/genetic study identified an ALS age of onset modifier

Abstract Age at onset of amyotrophic lateral sclerosis (ALS) is highly variable (eg, 27–74 years in carriers of the G4C2-expansion in C9orf72). It might be influenced by environmental and genetic factors via the modulation of DNA methylation (DNAm) at CpG-sites. Hence, we combined an epigenetic and...

Full description

Bibliographic Details
Main Authors: Ming Zhang, Zhengrui Xi, Sara Saez-Atienzar, Ruth Chia, Danielle Moreno, Christine Sato, Mahdi Montazer Haghighi, Bryan J. Traynor, Lorne Zinman, Ekaterina Rogaeva
Format: Article
Language:English
Published: BMC 2021-04-01
Series:Acta Neuropathologica Communications
Subjects:
ALS
Age of onset
Modifier
DNA methylation
CpG-SNPs
Genetic association
Online Access:https://doi.org/10.1186/s40478-021-01183-w

Internet

https://doi.org/10.1186/s40478-021-01183-w

Similar Items