Divergent patterns of selection on metabolite levels and gene expression

Divergent patterns of selection on metabolite levels and gene expression

Abstract Background Natural selection can act on multiple genes in the same pathway, leading to polygenic adaptation. For example, adaptive changes were found to down-regulate six genes involved in ergosterol biosynthesis—an essential pathway targeted by many antifungal drugs—in some strains of the...

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Bibliographic Details
Main Authors: Alexander F. Kern, Grace Xiaolu Yang, Neil M. Khosla, Roy Moh Lik Ang, Michael P. Snyder, Hunter B. Fraser
Format: Article
Language:English
Published: BMC 2021-09-01
Series:BMC Ecology and Evolution
Subjects:
Polygenic adaptation
Metabolism
Gene expression
Yeast
Ergosterol
Stabilizing selection
Online Access:https://doi.org/10.1186/s12862-021-01915-5

Internet

https://doi.org/10.1186/s12862-021-01915-5

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