Exocytosis regulates trafficking of GABA and glycine heterotransporters in spinal cord glutamatergic synapses: a mechanism for the excessive heterotransporter-induced release of glutamate in experimental amyotrophic lateral sclerosis

Exocytosis regulates trafficking of GABA and glycine heterotransporters in spinal cord glutamatergic synapses: a mechanism for the excessive heterotransporter-induced release of glutamate in experimental amyotrophic lateral sclerosis

The impact of synaptic vesicle endo-exocytosis on the trafficking of nerve terminal heterotransporters was studied by monitoring membrane expression and function of the GABA transporter-1 (GAT-1) and of type-1/2 glycine (Gly) transporters (GlyT-1/2) at spinal cord glutamatergic synaptic boutons. Exp...

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Bibliographic Details
Main Authors: Marco Milanese, Tiziana Bonifacino, Ernesto Fedele, Claudia Rebosio, Luca Cattaneo, Fabio Benfenati, Cesare Usai, Giambattista Bonanno
Format: Article
Language:English
Published: Elsevier 2015-02-01
Series:Neurobiology of Disease
Subjects:
GABA heterotransporter
Glycine heterotransporter
Transporter trafficking
Amyotrophic lateral sclerosis
SOD1G93A mice
Glutamate release
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996114003751

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http://www.sciencedirect.com/science/article/pii/S0969996114003751

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