Impaired CK1 delta activity attenuates SV40-induced cellular transformation in vitro and mouse mammary carcinogenesis in vivo.

Impaired CK1 delta activity attenuates SV40-induced cellular transformation in vitro and mouse mammary carcinogenesis in vivo.

Simian virus 40 (SV40) is a powerful tool to study cellular transformation in vitro, as well as tumor development and progression in vivo. Various cellular kinases, among them members of the CK1 family, play an important role in modulating the transforming activity of SV40, including the transformin...

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Bibliographic Details
Main Authors: Heidrun Hirner, Cagatay Günes, Joachim Bischof, Sonja Wolff, Arnhild Grothey, Marion Kühl, Franz Oswald, Florian Wegwitz, Michael R Bösl, Anna Trauzold, Doris Henne-Bruns, Christian Peifer, Frank Leithäuser, Wolfgang Deppert, Uwe Knippschild
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3250488?pdf=render

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http://europepmc.org/articles/PMC3250488?pdf=render

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