Azathioprine Biotransformation in Young Patients with Inflammatory Bowel Disease: Contribution of Glutathione-S Transferase M1 and A1 Variants

Azathioprine Biotransformation in Young Patients with Inflammatory Bowel Disease: Contribution of Glutathione-S Transferase M1 and A1 Variants

The contribution of candidate genetic variants involved in azathioprine biotransformation on azathioprine efficacy and pharmacokinetics in 111 young patients with inflammatory bowel disease was evaluated. Azathioprine doses, metabolites thioguanine-nucleotides (TGN) and methylmercaptopurine-nucleoti...

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Bibliographic Details
Main Authors: Marianna Lucafò, Gabriele Stocco, Stefano Martelossi, Diego Favretto, Raffaella Franca, Noelia Malusà, Angela Lora, Matteo Bramuzzo, Samuele Naviglio, Erika Cecchin, Giuseppe Toffoli, Alessandro Ventura, Giuliana Decorti
Format: Article
Language:English
Published: MDPI AG 2019-04-01
Series:Genes
Subjects:
azathioprine
inflammatory bowel disease
glutathione-S transferase
pharmacogenetics
pharmacokinetics
Online Access:https://www.mdpi.com/2073-4425/10/4/277

Internet

https://www.mdpi.com/2073-4425/10/4/277

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