Albumin/vaccine nanocomplexes that assemble in vivo for combination cancer immunotherapy

Albumin/vaccine nanocomplexes that assemble in vivo for combination cancer immunotherapy

Albumin conjugates can enhance drug delivery. Here, the authors repurpose albumin-binding Evans blue to develop nanovaccines that co-deliver adjuvants and tumor neoantigens to antigen-presenting cells in lymph nodes, resulting in potent and durable antitumour immunity in combination immunotherapy.

Bibliographic Details
Main Authors: Guizhi Zhu, Geoffrey M. Lynn, Orit Jacobson, Kai Chen, Yi Liu, Huimin Zhang, Ying Ma, Fuwu Zhang, Rui Tian, Qianqian Ni, Siyuan Cheng, Zhantong Wang, Nan Lu, Bryant C. Yung, Zhe Wang, Lixin Lang, Xiao Fu, Albert Jin, Ido D. Weiss, Harshad Vishwasrao, Gang Niu, Hari Shroff, Dennis M. Klinman, Robert A. Seder, Xiaoyuan Chen
Format: Article
Language:English
Published: Nature Publishing Group 2017-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-02191-y

Internet

https://doi.org/10.1038/s41467-017-02191-y

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