Methanol-Essential Growth of <i>Corynebacterium glutamicum</i>:<i> </i>Adaptive Laboratory Evolution Overcomes Limitation due to Methanethiol Assimilation Pathway

Methanol-Essential Growth of <i>Corynebacterium glutamicum</i>:<i> </i>Adaptive Laboratory Evolution Overcomes Limitation due to Methanethiol Assimilation Pathway

Methanol is a sustainable substrate for biotechnology. In addition to natural methylotrophs, metabolic engineering has gained attention for transfer of methylotrophy. Here, we engineered <i>Corynebacterium glutamicum</i> for methanol-dependent growth with a sugar co-substrate. Heterologo...

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Bibliographic Details
Main Authors: Guido Hennig, Carsten Haupka, Luciana F. Brito, Christian Rückert, Edern Cahoreau, Stéphanie Heux, Volker F. Wendisch
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:International Journal of Molecular Sciences
Subjects:
synthetic methylotrophy
methanol
ribulose monophosphate pathway
adaptive laboratory evolution
isotopic labeling
metabolic engineering
Online Access:https://www.mdpi.com/1422-0067/21/10/3617

Internet

https://www.mdpi.com/1422-0067/21/10/3617

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