Stable transplantation of human mitochondrial DNA by high-throughput, pressurized isolated mitochondrial delivery

Stable transplantation of human mitochondrial DNA by high-throughput, pressurized isolated mitochondrial delivery

Generating mammalian cells with specific mitochondrial DNA (mtDNA)–nuclear DNA (nDNA) combinations is desirable but difficult to achieve and would be enabling for studies of mitochondrial-nuclear communication and coordination in controlling cell fates and functions. We developed ‘MitoPunch’, a pres...

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Bibliographic Details
Main Authors: Alexander J Sercel, Alexander N Patananan, Tianxing Man, Ting-Hsiang Wu, Amy K Yu, Garret W Guyot, Shahrooz Rabizadeh, Kayvan R Niazi, Pei-Yu Chiou, Michael A Teitell
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-01-01
Series:eLife
Subjects:
mitochondrial dna
mitochondrial transplantation
MitoCeption
MitoPunch
mitochondrial transfer
stable isolated mitochondrial recipient
Online Access:https://elifesciences.org/articles/63102

Internet

https://elifesciences.org/articles/63102

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