VASP activation via the Gα13/RhoA/PKA pathway mediates cucurbitacin-B-induced actin aggregation and cofilin-actin rod formation.

VASP activation via the Gα13/RhoA/PKA pathway mediates cucurbitacin-B-induced actin aggregation and cofilin-actin rod formation.

Cucurbitacin B (CuB), a potent antineoplastic agent of cucurbitacin triterpenoids, induces rapid disruption of actin cytoskeleton and aberrant cell cycle inhibiting carcinogenesis. However, the underlying molecular mechanism of such anticancer effects remains incompletely understood. In this study,...

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Bibliographic Details
Main Authors: Yan-Ting Zhang, Li-Hui Xu, Qun Lu, Kun-Peng Liu, Pei-Yan Liu, Fang Ji, Xiao-Ming Liu, Dong-Yun Ouyang, Xian-Hui He
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3972149?pdf=render

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http://europepmc.org/articles/PMC3972149?pdf=render

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