Mutational Analysis of the GXXXG/A Motifs in the Human Na+/Taurocholate Co-Transporting Polypeptide NTCP on Its Bile Acid Transport Function and Hepatitis B/D Virus Receptor Function

Mutational Analysis of the GXXXG/A Motifs in the Human Na+/Taurocholate Co-Transporting Polypeptide NTCP on Its Bile Acid Transport Function and Hepatitis B/D Virus Receptor Function

Homodimerization is essential for plasma membrane sorting of the liver bile acid transporter NTCP and its function as Hepatitis B/D Virus (HBV/HDV) receptor. However, the protein domains involved in NTCP dimerization are unknown. NTCP bears two potential GXXXG/A dimerization motifs in its transmembr...

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Bibliographic Details
Main Authors: Massimo Palatini, Simon Franz Müller, Kira Alessandra Alicia Theresa Lowjaga, Saskia Noppes, Jörg Alber, Felix Lehmann, Nora Goldmann, Dieter Glebe, Joachim Geyer
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Molecular Biosciences
Subjects:
Na+/taurocholate co-transporting polypeptide
bile acid transport
dimerization
sorting
protein-protein interaction
hepatitis B virus
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2021.699443/full

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https://www.frontiersin.org/articles/10.3389/fmolb.2021.699443/full

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