Case Report: Detection of a Novel Germline PALB2 Deletion in a Young Woman With Hereditary Breast Cancer: When the Patient's Phenotype History Doesn't Lie

Case Report: Detection of a Novel Germline PALB2 Deletion in a Young Woman With Hereditary Breast Cancer: When the Patient's Phenotype History Doesn't Lie

The partner and localizer of BRCA2 (PALB2) is a major BRCA2 binding partner that participates in homologous recombination repair in response to DNA double-strand breaks. Germline alterations of the PALB2 gene have recently been associated with a high risk of developing breast cancer. We investigated...

Full description

Bibliographic Details
Main Authors: Carmine De Angelis, Carmela Nardelli, Paola Concolino, Martina Pagliuca, Mario Setaro, Elisa De Paolis, Pietro De Placido, Valeria Forestieri, Giovanni Luca Scaglione, Annalisa Ranieri, Barbara Lombardo, Lucio Pastore, Sabino De Placido, Ettore Capoluongo
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Oncology
Subjects:
hereditary breast cancer
PALB2
breast-cancer risk
deletion
surveillance
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.602523/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2021.602523/full

Similar Items