N-Linked Glycosylation on Anthrax Toxin Receptor 1 Is Essential for Seneca Valley Virus Infection

N-Linked Glycosylation on Anthrax Toxin Receptor 1 Is Essential for Seneca Valley Virus Infection

Seneca Valley virus (SVV) is a picornavirus with potency in selectively infecting and lysing cancerous cells. The cellular receptor for SVV mediating the selective tropism for tumors is anthrax toxin receptor 1 (ANTXR1), a type I transmembrane protein expressed in tumors. Similar to other mammalian...

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Bibliographic Details
Main Authors: Nadishka Jayawardena, Linde A. Miles, Laura N. Burga, Charles Rudin, Matthias Wolf, John T. Poirier, Mihnea Bostina
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Viruses
Subjects:
virus receptor interaction
receptor glycosylation
picornavirus
icosahedral capsid
cryo-electron microscopy
Online Access:https://www.mdpi.com/1999-4915/13/5/769

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https://www.mdpi.com/1999-4915/13/5/769

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